Cape Girardeau to Ponca City: Road Trip Guide & Distance

How far is Cape Girardeau from Ponca City?

The distance from Cape Girardeau to Ponca City is 419.5 miles (675.1 km) as the crow flies. Ponca City is located W of Cape Girardeau. By car, the driving distance is approximately 503.4 miles, taking about 10h 8min. A direct flight would take roughly 1h 21min. Both are located in United States — Cape Girardeau in Missouri and Ponca City in Oklahoma.

This is a solid day of driving. Be sure to take breaks every 2-3 hours to avoid driver fatigue, and plan your meals ahead of time. Since you'll be heading mostly West, pack a good pair of sunglasses if you plan to drive during the late afternoon to avoid the harsh sun glare.

Coordinates come from public place data for Cape Girardeau and Ponca City. The driving distance is estimated from straight-line distance with a road-factor model, so confirm the route in your navigation app. Fuel, flight, bus, and train values are planning estimates and can change by date, provider, road closures, and border rules.