Cape Girardeau to Odessa: Road Trip Guide & Distance

How far is Cape Girardeau from Odessa?

The distance from Cape Girardeau to Odessa is 821.6 miles (1322.2 km) as the crow flies. Odessa is located WSW of Cape Girardeau. By car, the driving distance is approximately 985.9 miles, taking about 19h 50min. A direct flight would take roughly 2h 9min. Both are located in United States — Cape Girardeau in Missouri and Odessa in Texas.

This is a serious multi-day road trip! We strongly recommend breaking this journey up with an overnight stay to ensure you arrive safely and refreshed. Since you'll be heading mostly West, pack a good pair of sunglasses if you plan to drive during the late afternoon to avoid the harsh sun glare. For a trip of this distance, flying is significantly faster. However, driving offers the flexibility to explore stops along the way.

Coordinates come from public place data for Cape Girardeau and Odessa. The driving distance is estimated from straight-line distance with a road-factor model, so confirm the route in your navigation app. Fuel, flight, bus, and train values are planning estimates and can change by date, provider, road closures, and border rules.