Cape Girardeau to Muskogee: Road Trip Guide & Distance

How far is Cape Girardeau from Muskogee?

The distance from Cape Girardeau to Muskogee is 342.2 miles (550.7 km) as the crow flies. Muskogee is located WSW of Cape Girardeau. By car, the driving distance is approximately 410.6 miles, taking about 8h 16min. A direct flight would take roughly 1h 11min. Both are located in United States — Cape Girardeau in Missouri and Muskogee in Oklahoma.

This is a solid day of driving. Be sure to take breaks every 2-3 hours to avoid driver fatigue, and plan your meals ahead of time. Since you'll be heading mostly West, pack a good pair of sunglasses if you plan to drive during the late afternoon to avoid the harsh sun glare.

Coordinates come from public place data for Cape Girardeau and Muskogee. The driving distance is estimated from straight-line distance with a road-factor model, so confirm the route in your navigation app. Fuel, flight, bus, and train values are planning estimates and can change by date, provider, road closures, and border rules.