Cape Girardeau to Manhattan: Road Trip Guide & Distance

How far is Cape Girardeau from Manhattan?

The distance from Cape Girardeau to Manhattan is 404 miles (650.2 km) as the crow flies. Manhattan is located WNW of Cape Girardeau. By car, the driving distance is approximately 484.8 miles, taking about 9h 45min. A direct flight would take roughly 1h 19min. Both are located in United States — Cape Girardeau in Missouri and Manhattan in Kansas.

This is a solid day of driving. Be sure to take breaks every 2-3 hours to avoid driver fatigue, and plan your meals ahead of time. Since you'll be heading mostly West, pack a good pair of sunglasses if you plan to drive during the late afternoon to avoid the harsh sun glare.

Coordinates come from public place data for Cape Girardeau and Manhattan. The driving distance is estimated from straight-line distance with a road-factor model, so confirm the route in your navigation app. Fuel, flight, bus, and train values are planning estimates and can change by date, provider, road closures, and border rules.