Cape Girardeau to Madisonville: Road Trip Guide & Distance

How far is Cape Girardeau from Madisonville?

The distance from Cape Girardeau to Madisonville is 111 miles (178.6 km) as the crow flies. Madisonville is located E of Cape Girardeau. By car, the driving distance is approximately 138.8 miles, taking about 2h 47min. A direct flight would take roughly 43min. Both are located in United States — Cape Girardeau in Missouri and Madisonville in Kentucky.

For a drive of this length, it's recommended to plan at least one quick rest stop to stretch your legs and grab a coffee. Heading East means you'll be driving into the sunrise if you start early. Keep your windshield clean for the best visibility. Given the short distance, driving or taking a train is often faster and more convenient than dealing with airport security and flight boarding times.

Coordinates come from public place data for Cape Girardeau and Madisonville. The driving distance is estimated from straight-line distance with a road-factor model, so confirm the route in your navigation app. Fuel, flight, bus, and train values are planning estimates and can change by date, provider, road closures, and border rules.