Cape Girardeau to Lafayette, Louisiana: Road Trip Guide & Distance

509.9 miles 820.6 km · straight line
611.9 miles estimated 984.7 km · driving distance
12h 19min estimated drive time
$59 - $72 estimated fuel cost
~1h 32min flight time
197° SSW bearing direction

How far is Cape Girardeau from Lafayette, Louisiana?

The distance from Cape Girardeau to Lafayette, Louisiana is 509.9 miles (820.6 km) as the crow flies. Lafayette, Louisiana is located SSW of Cape Girardeau. By car, the driving distance is approximately 611.9 miles, taking about 12h 19min. A direct flight would take roughly 1h 32min. Both are located in United States — Cape Girardeau in Missouri and Lafayette, Louisiana in Louisiana.

This is a serious multi-day road trip! We strongly recommend breaking this journey up with an overnight stay to ensure you arrive safely and refreshed. Since you'll be heading mostly West, pack a good pair of sunglasses if you plan to drive during the late afternoon to avoid the harsh sun glare.

Coordinates come from public place data for Cape Girardeau and Lafayette, Louisiana. The driving distance is estimated from straight-line distance with a road-factor model, so confirm the route in your navigation app. Fuel, flight, bus, and train values are planning estimates and can change by date, provider, road closures, and border rules.

How to Get from Cape Girardeau to Lafayette, Louisiana

Method Time Est. Cost Best For
Drive 12h 19min $59 - $72 Flexible stops
Fly ~1h 32min $80–200* Speed
Bus ~14h 47min $49–$92* Budget
Train ~16h 1min $73–$214* Comfort

Suggested Stops Between Cape Girardeau & Lafayette, Louisiana

Quick Facts

Cape Girardeau
37.31°N, 89.52°W
America/Chicago
108m elevation
Lafayette, Louisiana
30.22°N, 92.02°W
America/Chicago
11m elevation
Explore more routes from Lafayette, Louisiana

Did You Know?

  • At walking speed (3 mph), it would take about 170 hours of non-stop walking
  • By bicycle at 12 mph, the journey would take roughly 42 hours
  • You could travel this distance about 48.8 times to circle the Earth's equator
Data Sources & Estimate Notes GeoNames · OpenStreetMap · Driving distance estimated using road factor coefficients