Cape Girardeau to Lafayette, Indiana: Road Trip Guide & Distance

How far is Cape Girardeau from Lafayette, Indiana?

The distance from Cape Girardeau to Lafayette, Indiana is 257.7 miles (414.7 km) as the crow flies. Lafayette, Indiana is located NNE of Cape Girardeau. By car, the driving distance is approximately 322.1 miles, taking about 6h 29min. A direct flight would take roughly 1h 1min. Both are located in United States — Cape Girardeau in Missouri and Lafayette, Indiana in Indiana.

For a drive of this length, it's recommended to plan at least one quick rest stop to stretch your legs and grab a coffee. Heading East means you'll be driving into the sunrise if you start early. Keep your windshield clean for the best visibility.

Coordinates come from public place data for Cape Girardeau and Lafayette, Indiana. The driving distance is estimated from straight-line distance with a road-factor model, so confirm the route in your navigation app. Fuel, flight, bus, and train values are planning estimates and can change by date, provider, road closures, and border rules.