Cape Girardeau to Denison: Road Trip Guide & Distance

How far is Cape Girardeau from Denison?

The distance from Cape Girardeau to Denison is 464.5 miles (747.5 km) as the crow flies. Denison is located WSW of Cape Girardeau. By car, the driving distance is approximately 557.4 miles, taking about 11h 13min. A direct flight would take roughly 1h 26min. Both are located in United States — Cape Girardeau in Missouri and Denison in Texas.

This is a solid day of driving. Be sure to take breaks every 2-3 hours to avoid driver fatigue, and plan your meals ahead of time. Since you'll be heading mostly West, pack a good pair of sunglasses if you plan to drive during the late afternoon to avoid the harsh sun glare.

Coordinates come from public place data for Cape Girardeau and Denison. The driving distance is estimated from straight-line distance with a road-factor model, so confirm the route in your navigation app. Fuel, flight, bus, and train values are planning estimates and can change by date, provider, road closures, and border rules.