Cape Girardeau to Clarksdale: Road Trip Guide & Distance

How far is Cape Girardeau from Clarksdale?

The distance from Cape Girardeau to Clarksdale is 222.6 miles (358.2 km) as the crow flies. Clarksdale is located SSW of Cape Girardeau. By car, the driving distance is approximately 278.2 miles, taking about 5h 36min. A direct flight would take roughly 57min. Both are located in United States — Cape Girardeau in Missouri and Clarksdale in Mississippi.

For a drive of this length, it's recommended to plan at least one quick rest stop to stretch your legs and grab a coffee. Since you'll be heading mostly West, pack a good pair of sunglasses if you plan to drive during the late afternoon to avoid the harsh sun glare.

Coordinates come from public place data for Cape Girardeau and Clarksdale. The driving distance is estimated from straight-line distance with a road-factor model, so confirm the route in your navigation app. Fuel, flight, bus, and train values are planning estimates and can change by date, provider, road closures, and border rules.