Cancun to Key West: Road Trip Guide & Distance

How far is Cancun from Key West?

The distance from Cancun to Key West is 399 miles (642.1 km) as the crow flies. Key West is located NE of Cancun. By car, the driving distance is approximately 478.8 miles, taking about 9h 38min. A direct flight would take roughly 1h 18min. Cancun is in Mexico, while Key West is in Florida, United States.

This is a solid day of driving. Be sure to take breaks every 2-3 hours to avoid driver fatigue, and plan your meals ahead of time. Heading East means you'll be driving into the sunrise if you start early. Keep your windshield clean for the best visibility. Keep in mind this route crosses international borders. Don't forget your passport, and check current border crossing times and vehicle insurance requirements.

Coordinates come from public place data for Cancun and Key West. The driving distance is estimated from straight-line distance with a road-factor model, so confirm the route in your navigation app. Fuel, flight, bus, and train values are planning estimates and can change by date, provider, road closures, and border rules.