Buffalo, New York to O'Fallon, Missouri: Road Trip Guide & Distance

How far is Buffalo, New York from O'Fallon, Missouri?

The distance from Buffalo, New York to O'Fallon, Missouri is 678.2 miles (1091.4 km) as the crow flies. O'Fallon, Missouri is located WSW of Buffalo, New York. By car, the driving distance is approximately 813.8 miles, taking about 16h 22min. A direct flight would take roughly 1h 52min. Both are located in United States — Buffalo, New York in New York and O'Fallon, Missouri in Missouri.

This is a serious multi-day road trip! We strongly recommend breaking this journey up with an overnight stay to ensure you arrive safely and refreshed. Since you'll be heading mostly West, pack a good pair of sunglasses if you plan to drive during the late afternoon to avoid the harsh sun glare. For a trip of this distance, flying is significantly faster. However, driving offers the flexibility to explore stops along the way.

Coordinates come from public place data for Buffalo, New York and O'Fallon, Missouri. The driving distance is estimated from straight-line distance with a road-factor model, so confirm the route in your navigation app. Fuel, flight, bus, and train values are planning estimates and can change by date, provider, road closures, and border rules.