Biloxi to Siesta Key: Road Trip Guide & Distance

How far is Biloxi from Siesta Key?

The distance from Biloxi to Siesta Key is 440.2 miles (708.5 km) as the crow flies. Siesta Key is located ESE of Biloxi. By car, the driving distance is approximately 528.3 miles, taking about 10h 38min. A direct flight would take roughly 1h 23min. Both are located in United States — Biloxi in Mississippi and Siesta Key in Florida.

This is a solid day of driving. Be sure to take breaks every 2-3 hours to avoid driver fatigue, and plan your meals ahead of time. Heading East means you'll be driving into the sunrise if you start early. Keep your windshield clean for the best visibility.

Coordinates come from public place data for Biloxi and Siesta Key. The driving distance is estimated from straight-line distance with a road-factor model, so confirm the route in your navigation app. Fuel, flight, bus, and train values are planning estimates and can change by date, provider, road closures, and border rules.