Biloxi to Opelika: Road Trip Guide & Distance

How far is Biloxi from Opelika?

The distance from Biloxi to Opelika is 258.5 miles (416 km) as the crow flies. Opelika is located NE of Biloxi. By car, the driving distance is approximately 323.1 miles, taking about 6h 30min. A direct flight would take roughly 1h 1min. Both are located in United States — Biloxi in Mississippi and Opelika in Alabama.

For a drive of this length, it's recommended to plan at least one quick rest stop to stretch your legs and grab a coffee. Heading East means you'll be driving into the sunrise if you start early. Keep your windshield clean for the best visibility.

Coordinates come from public place data for Biloxi and Opelika. The driving distance is estimated from straight-line distance with a road-factor model, so confirm the route in your navigation app. Fuel, flight, bus, and train values are planning estimates and can change by date, provider, road closures, and border rules.