Biloxi to Hilton Head Island: Road Trip Guide & Distance

How far is Biloxi from Hilton Head Island?

The distance from Biloxi to Hilton Head Island is 496.2 miles (798.5 km) as the crow flies. Hilton Head Island is located ENE of Biloxi. By car, the driving distance is approximately 595.4 miles, taking about 11h 59min. A direct flight would take roughly 1h 30min. Both are located in United States — Biloxi in Mississippi and Hilton Head Island in South Carolina.

This is a solid day of driving. Be sure to take breaks every 2-3 hours to avoid driver fatigue, and plan your meals ahead of time. Heading East means you'll be driving into the sunrise if you start early. Keep your windshield clean for the best visibility.

Coordinates come from public place data for Biloxi and Hilton Head Island. The driving distance is estimated from straight-line distance with a road-factor model, so confirm the route in your navigation app. Fuel, flight, bus, and train values are planning estimates and can change by date, provider, road closures, and border rules.