Biloxi to Great Smoky Mountains: Road Trip Guide & Distance

How far is Biloxi from Great Smoky Mountains?

The distance from Biloxi to Great Smoky Mountains is 476.9 miles (767.5 km) as the crow flies. Great Smoky Mountains is located NE of Biloxi. By car, the driving distance is approximately 572.3 miles, taking about 11h 31min. A direct flight would take roughly 1h 28min. Both are located in United States — Biloxi in Mississippi and Great Smoky Mountains in Tennessee.

This is a solid day of driving. Be sure to take breaks every 2-3 hours to avoid driver fatigue, and plan your meals ahead of time. Heading East means you'll be driving into the sunrise if you start early. Keep your windshield clean for the best visibility.

Coordinates come from public place data for Biloxi and Great Smoky Mountains. The driving distance is estimated from straight-line distance with a road-factor model, so confirm the route in your navigation app. Fuel, flight, bus, and train values are planning estimates and can change by date, provider, road closures, and border rules.