Biloxi to Clarksdale: Road Trip Guide & Distance

How far is Biloxi from Clarksdale?

The distance from Biloxi to Clarksdale is 280.7 miles (451.7 km) as the crow flies. Clarksdale is located NNW of Biloxi. By car, the driving distance is approximately 350.8 miles, taking about 7h 3min. A direct flight would take roughly 1h 4min. Both are located in United States.

For a drive of this length, it's recommended to plan at least one quick rest stop to stretch your legs and grab a coffee. Since you'll be heading mostly West, pack a good pair of sunglasses if you plan to drive during the late afternoon to avoid the harsh sun glare.

Coordinates come from public place data for Biloxi and Clarksdale. The driving distance is estimated from straight-line distance with a road-factor model, so confirm the route in your navigation app. Fuel, flight, bus, and train values are planning estimates and can change by date, provider, road closures, and border rules.