Ames to St. Louis: Road Trip Guide & Distance

How far is Ames from St. Louis?

The distance from Ames to St. Louis is 296.4 miles (477 km) as the crow flies. St. Louis is located SE of Ames. By car, the driving distance is approximately 370.5 miles, taking about 7h 27min. A direct flight would take roughly 1h 6min. Both are located in United States — Ames in Iowa and St. Louis in Missouri.

This is a solid day of driving. Be sure to take breaks every 2-3 hours to avoid driver fatigue, and plan your meals ahead of time. Heading East means you'll be driving into the sunrise if you start early. Keep your windshield clean for the best visibility.

Coordinates come from public place data for Ames and St. Louis. The driving distance is estimated from straight-line distance with a road-factor model, so confirm the route in your navigation app. Fuel, flight, bus, and train values are planning estimates and can change by date, provider, road closures, and border rules.