Amarillo to Tupelo: Road Trip Guide & Distance

How far is Amarillo from Tupelo?

The distance from Amarillo to Tupelo is 747.7 miles (1203.3 km) as the crow flies. Tupelo is located E of Amarillo. By car, the driving distance is approximately 897.3 miles, taking about 18h 3min. A direct flight would take roughly 2h 0min. Both are located in United States — Amarillo in Texas and Tupelo in Mississippi.

This is a serious multi-day road trip! We strongly recommend breaking this journey up with an overnight stay to ensure you arrive safely and refreshed. Heading East means you'll be driving into the sunrise if you start early. Keep your windshield clean for the best visibility. For a trip of this distance, flying is significantly faster. However, driving offers the flexibility to explore stops along the way.

Coordinates come from public place data for Amarillo and Tupelo. The driving distance is estimated from straight-line distance with a road-factor model, so confirm the route in your navigation app. Fuel, flight, bus, and train values are planning estimates and can change by date, provider, road closures, and border rules.