Amarillo to Knoxville: Road Trip Guide & Distance

How far is Amarillo from Knoxville?

The distance from Amarillo to Knoxville is 1006.2 miles (1619.3 km) as the crow flies. Knoxville is located E of Amarillo. By car, the driving distance is approximately 1207.4 miles, taking about 24h 17min. A direct flight would take roughly 2h 31min. Both are located in United States — Amarillo in Texas and Knoxville in Tennessee.

This is a serious multi-day road trip! We strongly recommend breaking this journey up with an overnight stay to ensure you arrive safely and refreshed. Heading East means you'll be driving into the sunrise if you start early. Keep your windshield clean for the best visibility. For a trip of this distance, flying is significantly faster. However, driving offers the flexibility to explore stops along the way.

Coordinates come from public place data for Amarillo and Knoxville. The driving distance is estimated from straight-line distance with a road-factor model, so confirm the route in your navigation app. Fuel, flight, bus, and train values are planning estimates and can change by date, provider, road closures, and border rules.